<b>Calcium-activated potassium current in presynaptic terminals </b>
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چکیده
منابع مشابه
Calcium-activated potassium conductance in presynaptic terminals at the crayfish neuromuscular junction
Membrane potential changes that typically evoke transmitter release were studied by recording intracellularly from the excitor axon near presynaptic terminals of the crayfish opener neuromuscular junction. Depolarization of the presynaptic terminal with intracellular current pulses activated a conductance that caused a decrease in depolarization during the constant current pulse. This conductan...
متن کاملPresynaptic Terminals
Fluorescent indicators were used to detect stimulus-evoked changes in presynaptic levels of intracellular sodium (Na1) and calcium (Ca1) in granule cell parallel fibers in brain slices from rat cerebellum. Ca, increased during stimulation, and three exponentials were needed to approximate its return to prestimulus levels. Ca, decayed to -10% of peak levels with T 100 ms, to -1% of peak values w...
متن کاملDistribution of calcium and potassium in presynaptic nerve terminals from cerebellar cortex.
The elemental composition of the presynaptic nerve terminals in rapidly frozen synapses of the cerebellar molecular layer was determined by electron probe x-ray microanalysis and elemental imaging of characteristic x-rays. Elemental imaging of thin freeze-dried cryosections from fresh cerebellar slices frozen within 20 sec of removal from the brain showed normal concentrations of potassium (95 ...
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In the last years it has been increasingly clear that KV-channel activity modulates neurotransmitter release. The subcellular localization and composition of potassium channels are crucial to understanding its influence on neurotransmitter release. To investigate the role of KV in corticostriatal synapses modulation, we combined extracellular recording of population-spike and pharmacological bl...
متن کاملExcitement about Inhibitory Presynaptic Terminals
Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (2015) show that at Purkinje cell-deep cerebellar nuclei neuron synapses, chang...
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ژورنال
عنوان ژورنال: Biomedical Research
سال: 1984
ISSN: 0388-6107,1880-313X
DOI: 10.2220/biomedres.5.287